sigma 醋氨酚BioXtra

sigma 醋氨酚BioXtra

产品编号 A7085 | CAS号 103-90-2 | SIGMA-ALDRICH

Application:镇痛剂。

包装:1 kg in glass bottle,100, 500 g in glass bottle

Related Categories Building Blocks, C6 to C8, Chemical Synthesis, Organic Building Blocks, Oxygen Compounds,

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product line BioXtra
assay ≥99.0%
form powder
impurities ≤0.0005% Phosphorus (P)
≤0.1% Insoluble matter
ign. residue ≤0.1%
mp 168-172 °C(lit.)

Sigma 阿霉素 盐酸盐

Sigma 阿霉素 盐酸盐
产品编号 D1515 | CAS号 25316-40-9 | SIGMA

Frequently Asked Questions

Frequently Asked Questions are available for this Product.
包装:10 mg in glass bottle Biochem/physiol Actions
Naturally fluorescent anthracycline antibiotic, anticancer drug. Doxorubicin is a substrate of MRP1 which was first cloned from a DOX-resistant lung cancer cell line. Fluorescent property has been exploited for the measurement of drug efflux pump activities as well as resolving the important question of intracellular localization of various multidrug resistance proteins and the role of subcellular organelles (Golgi and lysosome) in the sequestration of drugs and its implication in drug resistant phenotypes.
法律信息
Adriamycin 为以下机构的注册商标: RDF Pharmacia & Upjohn S.P.A.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics,

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assay 98.0-102.0% (HPLC)
mp 216 °C (dec.)(lit.)
solubility H2O: soluble50 mg/mL, clear
Mode of action DNA synthesis | interferes
antibiotic activity spectrum viruses
storage temp. 2-8°C

Sigma 放线菌素 D

Sigma 放线菌素 D

产品编号 A9415 | CAS号 50-76-0 | SIGMA

Frequently Asked Questions

Frequently Asked Questions are available for this Product.
Application
Actinomycin D is an antineoplastic antibiotic that inhibits cell proliferation with wide-ranging applications ranging from a selection agent in cell culture, use in studies of suppressing HIV-replication and programmed cell death of PC12 cells, and as an antibiotic in treatment of various malignant neoplasms, including Wilm′s tumour and the sarcomas. Recommended for us in cell culture applications at 1μg/mL.
Caution
This product is hygroscopic and light-sensitive. If stored protected from light and moisture at 2-8°C, it remains unchanged, by HPLC testing, for at least 15 months. Unused dilute solutions of Actinomycin D are extremely sensitive to light and tend to adsorb to plastic and glass and should be discarded. However, frozen aliquots of concentrated stock solution are stable for at least a month.
包装:2, 5, 10, 25 mg in glass bottle
Preparation Note
Actinomycin D is sold as red, shiny crystals and is soluble in acetonitrilie or acetone at 10 mg/mL and in DMSO at a minimum of 1 mg/mL. Some references also show slight solubility in water of 0.5 mg/mL.
Biochem/physiol Actions
Actinomycin D inhibits the proliferation of cells by forming a stable complex with double-stranded DNA, inhibiting DNA-primed RNA synthesis and causing single-stranded breaks in DNA. It has been shown to be an inhibitor of the minus-strand transfer step in reverse transcriptase.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information