产品基本信息

货号：2070

产品名称：荧光淬灭剂Tide Quencher 4WS-DBCO [TQ4WS-DBCO]

规格：1mg

储存条件：-15℃避光防潮

保质期：12个月

产品物理化学光谱特性

分子量：1158.49

外观：固体

溶剂：DMSO

产品介绍

TQ4WS 是一种优于 ROX、TF4、iFluor 594、Alexa Fluor® 594 和 Texas Red® 的淬灭剂。 TQ4WS 具有 (a)更强的吸收； (b)更高的淬火效率；(c)具有所需溶解度的多功能反应形式，用于标记寡核苷酸和肽。这种 TQ4WS-DBCO 产品在无铜条件下与叠氮化物发生反应，可用于点击化学。 DBCO 可能是菌株促进的炔-叠氮化物环加成 (SPAAC) 中最常见的炔烃，也称为无铜点击反应。环辛炔和叠氮化物仅能有效地相互反应，同时对天然存在的官能团（如胺）保持惰性。 SPAAC 通过形成稳定的三唑，在水性和其他复杂化学环境中无需任何辅助试剂即可标记各种生物分子。 DBCO（二苯并环辛炔）化合物包含一类在水性缓冲液中具有相当快的动力学和良好稳定性的试剂。在生理温度和 pH 范围内，DBCO 基团不会与许多生物分子中天然存在的胺或羟基反应。此外，DBCO 基团与叠氮化物基团的反应明显快于与巯基（-SH，硫醇）的反应。金畔生物是AAT Bioquest的中国代理商，为您提供最优质的荧光淬灭剂。 

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参考文献

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Development of a Cancer Vaccine Using In Vivo Click-Chemistry-Mediated Active Lymph Node Accumulation for Improved Immunotherapy.
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In vivo vocal fold augmentation using an injectable polyethylene glycol hydrogel based on click chemistry.
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Understanding selectivity of metabolic labelling and click-targeting in multicellular environments as a route to tissue selective drug delivery.
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