肽底物Mca-YVADAPK(Dnp)-OH 货号13557-AAT Bioquest荧光染料

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肽底物Mca-YVADAPK(Dnp)-OH

肽底物Mca-YVADAPK(Dnp)-OH

肽底物Mca-YVADAPK(Dnp)-OH    货号13557 货号 13557 存储条件 在零下15度以下保存, 避免光照
规格 1 mg 价格 1836
Ex (nm) 322 Em (nm) 381
分子量 1145.15 溶剂 DMSO
产品详细介绍

简要概述

产品基本信息

货号:13557

产品名称:Mca-YVADAPK(Dnp)-OH

规格:1 mg

储存条件:-15℃避光防潮

保质期:24个月

 

产品物理化学光谱特性

分子量:1145.15

激发波长(nm):322

发射波长(nm):381

校正因子(280 nm):0.3

溶剂:水

 

产品介绍

Mca-YVADAPK(Dnp)-OH是一种荧光肽底物,用于检测caspase-1 /白介素转换酶(ICE)和血管紧张素I转换酶2(ACE-2)。它的N端包含高荧光的7-甲氧基香豆素(MCA)荧光团,可通过荧光共振能量转移(暗FRET)有效地淬灭赖氨酸残基上的非荧光2,4-二硝基苯基。它可以用于测量caspase-1 /白介素转化酶(ICE)和血管紧张素I转化酶2(ACE-2)的活性,这些酶能够裂解荧光基团(MCA)和荧光素之间的酰胺键。淬灭剂组(DNP),导致荧光增强。

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参考文献

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Journal: medRxiv : the preprint server for health sciences (2020)

ACE2 receptor polymorphism: Susceptibility to SARS-CoV-2, hypertension, multi-organ failure, and COVID-19 disease outcome.
Authors: Devaux, Christian A and Rolain, Jean-Marc and Raoult, Didier
Journal: Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi (2020): 425-435

Analysis of the susceptibility of lung cancer patients to SARS-CoV-2 infection.
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Journal: Molecular cancer (2020): 80

Animal models of mechanisms of SARS-CoV-2 infection and COVID-19 pathology.
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Journal: British journal of pharmacology (2020)

Autophagy as an emerging target for COVID-19: lessons from an old friend, chloroquine.
Authors: Bonam, Srinivasa Reddy and Muller, Sylviane and Bayry, Jagadeesh and Klionsky, Daniel J
Journal: Autophagy (2020): 1-7

Broad Host Range of SARS-CoV-2 Predicted by Comparative and Structural Analysis of ACE2 in Vertebrates.
Authors: Damas, Joana and Hughes, Graham M and Keough, Kathleen C and Painter, Corrie A and Persky, Nicole S and Corbo, Marco and Hiller, Michael and Koepfli, Klaus-Peter and Pfenning, Andreas R and Zhao, Huabin and Genereux, Diane P and Swofford, Ross and Pollard, Katherine S and Ryder, Oliver A and Nweeia, Martin T and Lindblad-Toh, Kerstin and Teeling, Emma C and Karlsson, Elinor K and Lewin, Harris A
Journal: bioRxiv : the preprint server for biology (2020)

Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates.
Authors: Damas, Joana and Hughes, Graham M and Keough, Kathleen C and Painter, Corrie A and Persky, Nicole S and Corbo, Marco and Hiller, Michael and Koepfli, Klaus-Peter and Pfenning, Andreas R and Zhao, Huabin and Genereux, Diane P and Swofford, Ross and Pollard, Katherine S and Ryder, Oliver A and Nweeia, Martin T and Lindblad-Toh, Kerstin and Teeling, Emma C and Karlsson, Elinor K and Lewin, Harris A
Journal: Proceedings of the National Academy of Sciences of the United States of America (2020): 22311-22322

Elevated FiO2 increases SARS-CoV-2 co-receptor expression in respiratory tract epithelium.
Authors: Myti, Despoina and Gunjak, Miša and Casado, Francisco and Khaghani Raziabad, Solmaz and Nardiello, Claudio and Vadász, István and Herold, Susanne and Pryhuber, Gloria and Seeger, Werner and Morty, Rory E
Journal: American journal of physiology. Lung cellular and molecular physiology (2020): L670-L674

Expression of SARS-CoV-2 Entry Molecules ACE2 and TMPRSS2 in the Gut of Patients With IBD.
Authors: Burgueño, Juan F and Reich, Adrian and Hazime, Hajar and Quintero, Maria A and Fernandez, Irina and Fritsch, Julia and Santander, Ana M and Brito, Nivis and Damas, Oriana M and Deshpande, Amar and Kerman, David H and Zhang, Lanyu and Gao, Zhen and Ban, Yuguang and Wang, Lily and Pignac-Kobinger, Judith and Abreu, Maria T
Journal: Inflammatory bowel diseases (2020): 797-808

Hypercytokinemia and Pathogen-Host Interaction in COVID-19.
Authors: Badawi, Alaa
Journal: Journal of inflammation research (2020): 255-261

说明书
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